#Automute protein full#

Protein database searches for multiple alignments.

Agmenellum quadruplicatum M.AquI, a novel modification methylase. PROMOT: a FORTRAN program to scan protein sequences against a library of known motifs. MacPattern: protein pattern searching on the Apple Macintosh. A flexible method to align large numbers of biological sequences. A workbench for multiple alignment construction and analysis. Sequence and expression in Escherichia coli of structural and repressor genes. Pseudomonas cepacia 2,2-dialkylglycine decarboxylase. Keller JW, Baurick KB, Rutt GC, O'Malley MV, Sonafrank NL, Reynolds RA, Ebbesson LO, Vajdos FF.Cloning and sequencing of protochlorophyllide reductase. Darrah PM, Kay SA, Teakle GR, Griffiths WT.Nucleotide sequence of a cDNA coding for the NADPH-protochlorophyllide oxidoreductase (PCR) of barley (Hordeum vulgare L.) and its expression in Escherichia coli. Schulz R, Steinmüller K, Klaas M, Forreiter C, Rasmussen S, Hiller C, Apel K.Isolation and expression of rat liver sepiapterin reductase cDNA. Citron BA, Milstien S, Gutierrez JC, Levine RA, Yanak BL, Kaufman S.Multiple sequence alignment of protein families showing low sequence homology: a methodological approach using database pattern-matching discriminators for G-protein-linked receptors. Attwood TK, Eliopoulos EE, Findlay JB.Rapid and sensitive sequence comparison with FASTP and FASTA.

Understanding structural relationships in proteins of unsolved three-dimensional structure. The SWISS-PROT protein sequence data bank. A fast and sensitive multiple sequence alignment algorithm. PROSITE: a dictionary of sites and patterns in proteins. Finding sequence motifs in groups of functionally related proteins. Automatic generation of primary sequence patterns from sets of related protein sequences. Finding protein similarities with nucleotide sequence databases. Links to PubMed are also available for Selected References. Get a printable copy (PDF file) of the complete article (1.6M), or click on a page image below to browse page by page.

#Automute protein full#

Full textįull text is available as a scanned copy of the original print version. The practical use of the blocks database is demonstrated by detecting previously unknown relationships between oxidoreductases and by evaluating a proposed relationship between HIV Vif protein and thiol proteases. Examples are provided in which distant relationships are detected either using a set of blocks to search a sequence database or using sequences to search the database of blocks. Each block was calibrated by searching the SWISS-PROT database to obtain a measure of the chance distribution of matches, and the calibrated blocks were concatenated into a database that could itself be searched. When the automated system was applied successively to all 437 groups of related proteins in the PROSITE catalog, 1764 blocks resulted these could be used for very sensitive searches of sequence databases. Next, the local alignments are converted to blocks and the best set of non-overlapping blocks is determined. First, an automated version of Smith's algorithm for finding motifs is used for sensitive detection of multiple local alignments. A system is described for finding and assembling the most highly conserved regions of related proteins for database searching.